Samuel’s latest injury adds to a history of frustrating, short-term setbacks. Since he entered the NFL in 2019, Samuel has struggled to finish a full season, sidelined by injuries to his groin, foot, hamstring, ankle, knee, and shoulder.

San Francisco’s current wide receiver corps features Brandon Aiyuk, Jauan Jennings, Jacob Cowing, Chris Conley, and Ronnie Bell to cover for Samuel’s absence.

The 49ers also have an open roster spot due to McCaffrey’s placement on IR. Shanahan, however, remains unsure whether he’ll use that spot to bring in another receiver or running back.

San Francisco has three healthy running backs: rookie Isaac Guerendo, Patrick Taylor Jr., and Jordan Mason. Guerendo has had one carry for no yards, while Taylor has only played on special teams.

Deebo Samuel had been showing promise after a strong training camp, and Kyle Shanahan noted he was pleased with his performance in the two games before the injury.